Quantitative 99mTc-albumin colloid Nasal Mucociliary Clearance as outcome in primary ciliary dyskinesia

Background Primary ciliary dyskinesia (PCD) is an inherited disorder where dyskinetic cilia cause impaired mucociliary clearance (MC) of upper and lower airways. Airway movement can be indirectly tested in vivo after administration a radiolabeled tracer to the airways for assessment pulmonary MC or nose assessing Nasal (NMC). With this study we aimed investigate NMC as quantifiable outcome parameter PCD. Material Methods This single centre proof-of-concept on velocity investigated patients with PCD across different genotypes nasal Nitric Oxide (nNO) levels. Healthy controls (HC) were used comparison. was determined mm*min −1 nasally applied 99m Tc-albumin colloid tracer. By use gamma camera, repeated dynamic series images each lasting 30 s acquired during 10-minute period digitally stored. Results seven (aged 9 31 years) five adult HC's. Mean HC's (8.5 ) significantly higher compared (0.00 ), p<0.0001). completely absent all included regardless nNO values. Success rate 100% both groups. Conclusion discriminated highly significant between We suggest here fast feasible set up measurements that easily applicable any clinical trial involving medication compartment, step before parallel moving into lungs.